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This finding correlates with those described by Kumar et al., who demonstrated that ER is crucial to enhance OLs production, myelin protein synthesis, remyelination, and axon conduction in EAE mice through the activation of the PI3K/Akt/mTOR signaling pathway, without disturbing inflammation in the corpus callosum or spinal cord (Kumar et al., 2013

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doi: 10.3389/fphar.2018.00453 Received 28 February 2018 Accepted 18 April 2018 Published 15 May 2018 Volume 9 - 2018 Edited by Nabil Eid, Osaka Medical College, Japan Reviewed by Hartmut Jaeschke, University of Kansas Medical Center, United States

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