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In addition to promoting the expression of lysosomal genes, T 3 increases the expression of lysosomal-associated membrane protein (LAMP) [48, 49], which is a protein associated with stabilizing lysosomes and enhancing their resistance to the autophagosome burden activity to enhance the lysosomal activity [50]

This formulary decision comes despite clinical trial data, particularly the SURMOUNT-5 trial, which demonstrated greater total body weight loss with Zepbound compared to Wegovy

Dig Dis Sci 2013;58:172-8.PubMed 71

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