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In animal models, MOTS-c significantly reduced bone loss in ovariectomized mice (mimicking menopause) through dual mechanisms: promoting osteoblast differentiation and inhibiting osteoclast formation

Sequential schedulingfor example, priming with ferroptosis inducers to activate antitumor immunity before introducing cuproptosis-targeted agentsmay be required to avoid premature immunosuppression and achieve true synergy

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Daily use is actually recommended to maintain results from a dermatological standpoint