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The increased availability of biosimilars for GLP-1 receptor agonists provides cost-effective options, stimulating competition and perhaps decreasing treatment prices, hence boosting market accessibility

doi: 10.1016/j.jnutbio.2018.07.009 70 ZhaoLChenYXiaFAbudukerimuBZhangWGuoYet al

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Furthermore, compelling evidence implicates this local, brainstem-derived GLP-1, rather than gut-derived GLP-1, as a principal modulator of physiological GLP-1R dependent signals that regulate appetite and body weight (Drucker and Asa, 1988