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Another explanation is that the molar concentrations of the other five IGFBPs far exceeds the concentration of IGFBP-1 (39), and as they are not fully saturated, the other five IGFBPs are fully capable of sequestering the increase in free IGF-I secondary to the reductions in circulating IGFBP-1

However, the amount of alcohol consumed seems to have an impact

There are two potential reasons your belly fat may be stubborn: Genetic predisposition: Women are more likely to have fat thats extremely difficult to lose in their lower abdomen (many call this a belly pouch), whereas men tend to hold stubborn fat in their love handles, and some men have a harder time losing the visceral fat thats below their abdominal muscle