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BenchenaneKBerezowskiVAliCFernndez-MonrealMLpez-AtalayaJPBrillaultJet alTissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptorrelated protein-mediated transcytosis

This doesnt necessarily mean GLP-1s are bad, but there is a chance that future safety concerns will surface

Based on domain architecture comparison with HNF4 58,59 , we engineered an NHR-49 truncation (295422) to disrupt ligand binding by removing a majority of the ligand binding domain, while retaining its analogous N-terminal, DNA-binding, hinge, and C-terminal domains (Fig

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