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FXR activation decreases FFAR2 Gq-signaling in GLUTag L-cells To investigate whether FXR activation impacts on FFAR2-activated downstream Gq-signaling 6 , the influence of FXR activation on the SCFA-induced Ca 2+ response and inositol tri-phosphate (IP3) production (Gq intracellular effectors) in GLUTag L-cells was evaluated