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In addition to direct signaling, ghrelin has also been shown to affect food intake and metabolism at least partly via vagal afferent neurons in the nodose ganglion that express GHRS (Davis et al., 2020

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This link between cysteine-oxidative catabolism-derived pyruvate and cancer has been described in pancreatic cancer 73 and non-small lung cancer cells, 69 although additional studies that focus on other cancer types are required to strengthen this association