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Compounds in this category are studied in preclinical research models examining the incretin axis GLP-1, GIP, glucagon, and amylin receptor pharmacology

These included: Nausea (most frequently reported) Vomiting Diarrhoea Constipation Decreased appetite These effects were generally dose-dependent and transient , tending to occur during the dose escalation phase and resolving or diminishing over time

Black pepper Standardized extract Working in synergy with the other ingredients, the combination of black pepper is capable of increasing the absorption of curcumin