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DawiJMisakyanYAffaSKadesSNarasimhanAHajjarFet al

Similarly, after approximately one year, children using this same maximally tolerated or maintenance dose combined with diet and exercise dropped their average BMI by 16 percent compared to those only following a reduction in calories through diet and exercise

Excitingly, we found that as determined by metabolomics, the significant enrichment of sphingolipid metabolism and glycerophospholipid metabolism closely resembled the changes in metabolic pathways such as lipid metabolism in the gut microbiota that were predicted by PICRUSt based on 16S rRNA sequencing data

Results are expected in late 2025