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Ogino K, Izumi Y, Segawa H, Takeyama Y, Ishiyama H, Houbara T, et al

Clinical trials of semaglutide in the SUSTAIN and STEP programs demonstrated average weight loss of 15% to 22% of baseline body weight over 68 weeks, with many participants achieving these results as monotherapy

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Multiple cellular processes are considered to contribute to this functional decline and these are collectively referred to as the hallmarks of aging and these include processes like genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis 1