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7,11,1318,20,21 Intrinsic Chronologically Aged Skin Intrinsic or chronological factors influencing skin aging go beyond the passage of time, but also incorporate several factors like: genetics, metabolic, hormonal, immunological, cardiovascular, gastrointestinal, degenerative, and neoplastic diseases along with psychogenic (involving stress or affective disorders) (Figure 2)

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Glutathione S-transferase (GSTM1 and GSTT1) polymorphisms relationship between glycemic control of diabetic mothers and their infants