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PARP inhibitors for men with mCRPC and BRCA1 , BRCA2 , or ATM variants Olaparib Evidence (olaparib): The PARP inhibitor olaparib was tested in an open-label, phase III, randomized controlled trial in men with mCRPC and variants in one of 15 prespecified homologous recombination repair genes, including BRCA1 or BRCA2