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Increased advanced glycation end-product production in diabetes is accompanied by lower pericyte and endothelial tight junction coverage in the cortical capillaries of old diabetic rats [81]

In this light, we focus on one of the complications of chronically uncontrolled hyperglycemia: end-stage kidney disease, which necessitates kidney replacement therapy

And you know, the first thing I think about, I have several patients with cholesterol that's at a level that's beyond, you know, anything that I've ever seen