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Methods This retrospective cohort study was exempt from ethical review and informed consent because it was a secondary analysis of existing data, did not involve intervention or interaction with human participants, and used deidentified data per the deidentification standard defined in section 164.514(a) of the HIPAA Privacy Rule

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To investigate whether glutamine metabolites were responsible for the amplifying action of glutamine, we measured GLP-1 secretion in cells permeabilised by -haemolysin

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