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It is known that cellular homeostasis decreases with cellular aging

That is normal and expected

doi: 10.3390/nu10060706 258

Expression of hepatocyte growth factor and c-Met in the anterior horn cells of the spinal cord in the patients with amyotrophic lateral sclerosis (ALS): Immunohistochemical studies on sporadic ALS and familial ALS with superoxide dismutase 1 gene mutation