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While ROS generation is a natural part of cellular metabolism, the balance between ROS production and antioxidant defenses is key to preventing oxidative stress and ensuring proper cellular function 54

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Based on clinically available variables (BMI, waist circumference, OGTT/HOMA-IR, lipid profiles, NAFLD assessments, androgens, SHBG, and ultrasound markers), interpretable risk stratification models should be established rather than replacing clinical logic with black-box algorithms (173, 174)