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In a placebo-controlled RCT, Sharafkhan et al

In patients with hepatic encephalopathy, the impaired reaction of cerebral oxyhemoglobin concentration might occur due to astrocyte swelling and dysfunction 42,43,44 because some reports showed that astrocyte controls the regional cerebral blood flow and provides energy sources such as ketone body and carnitine to the neuron 39,41

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showed that L-carnitine supplementation in women with polycystic ovary syndrome (PCOs) improves glycemic status and reduces insulin resistance (101) which can be due to the increase in basal metabolic rate and lean body mass, as well as weight loss and improvement of related indices (102, 103)