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Researchers also examined metabolic and liver-related measurements

Antidepressant monotherapy is not recommended to treat bipolar depression [7, 13], highlighting the need to understand the biological mechanisms specific to bipolar depression

Without sufficient NAD+, these enzymes cannot functionwhich explains why the decline in NAD+ with age leads to a cascade of cellular dysfunctions (Katsyuba et al., Nat Metab 2020)