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Pure speculation based on experiments with heavy water suggests that histidine may be able to trap deuterium in its imidazole ring, and copper may serve as a catalyst for this by inducing proton currents

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L-carnitine supplementation had a significant effect on TG (WMD = 13.50 mg/dl), LDL (WMD = 12.66 mg/dl), HbA1c (WMD = -0.37%), FBG (WMD = 6.24 mg/dl), HOMA-IR (WMD = -0.72), CRP (WMD = 0.07 mg/dl), TNF- (WMD = 1.39 pg/ml), weight (WMD = 1.58 kg), BFP (WMD = 1.83), BMI (WMD = 0.28 kg/m2), and leptin (WMD = 2.21 ng/ml) in intervention, compared to the placebo group, in the pooled analysis