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Comparisons between the pill group and patch group found that people in the patch group were more likely to have nutritional deficiencies, including vitamins B1, B12, and D

Oral supplements typically increase levels within one to two weeks, with normalisation taking three to six months depending on deficiency severity

Vitamin B12 deficiency often occurs even when individuals consume a plentiful supply of B12 through their diet

Thus, going forward, it will be important to focus on dynamic changes observed in those proteins associated with mucosal barrier properties, rather than simply documenting terminal modifications as they are expressed in chronically inflamed mucosa