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Several theoretical mechanisms might explain why some patients notice sleep changes: Metabolic shifts : As the body adapts to reduced caloric intake and begins utilising fat stores, hormonal fluctuations may theoretically affect sleep-wake cycles Gastrointestinal discomfort : Nausea or abdominal discomfort, particularly if experienced during evening hours, may interfere with sleep onset or maintenance Changes in eating patterns : Altered meal timing or reduced evening food intake might affect circadian rhythms in susceptible individuals Indirect effects : The medication's impact on blood glucose regulation could theoretically influence sleep quality, though this mechanism remains speculative It is important to note that correlation does not imply causation

PMID: 41090431