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The mismatch between clinical indication and demand for GLP-1s in New York City is primarily attributable to off-label use (i.e., utilization by patients without Type 2 diabetes)

Traditionally, options were limited to painkillers, steroids, or surgery

A replicate design was applied so that the within-participant variability for the reference product (1G oral semaglutide) could be determined, to enable the application of widened or reference-scaled bioequivalence acceptance criteria for highly variable drugs [28, 29]