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doi: 10.3389/fonc.2026.1748136 Received 18 November 2025 Revised 23 March 2026 Accepted 24 March 2026 Published 30 April 2026 Volume 16 - 2026 Edited by Pierfranco Conte, University of Padua, Italy Reviewed by Valeria Conti, University of Salerno, Italy T Mohan Viswanathan, Karpagam Academy of Higher Education, India Updates Copyright 2026 Talath, El-Tanani, Wali, Rabbani, Bhongande, Ibraheem, Avagimyan, Hoffmann, Ilias, Ispas, Viviana, Paczkowska and Rizzo

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We further demonstrate that a senolytic FOXO4-D-retro-inverso-isoform peptide (FOXO4-DRI) promotes apoptosis and decreases G0/G1 phase cells in pro-senescence models of keloid organ cultures and fibroblasts, accompanied with p53-pS15 nuclear exclusion

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