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The trial was stopped early because the benefits were so clear.2 WHAT THE FLOW TRIAL FOUND The FLOW trial enrolled 3,533 adults with type 2 diabetes and chronic kidney disease across multiple countries

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2.2 Indications The currently approved indications for these agents include: Type 2 diabetes mellitus Overweight and obesity Beyond diabetes and obesity, further indications under investigation for GLP1 RAs include: Osteoarthritis Obstructive sleep apnea Metabolic dysfunction-associated steatotic liver disease Metabolic dysfunction-associated steatohepatitis 2.3 Benefits and Harms of Continuation/Discontinuation in the Perioperative Period: 2.3.1 Benefits: According to the guidelines, the acute use of these drugs may offer benefits based on published data: Improved perioperative glycemic control Lower postoperative insulin requirements Reduced risk of hypoglycemia These benefits may lead to reduced complications associated with hyperglycemia (such as a shorter hospital stay, fewer surgical site infections, less acute kidney injury, fewer acute coronary syndromes, reduced critical care admissions, and shorter durations on a ventilator) Improved cardiovascular outcomes 2.3.2 Harms There is an increased risk of pulmonary aspiration

Depending on how quickly you are able to increase the dosage and how closely you are following the other components of your medical weight loss treatment, initial results will likely start to become visible after 8 to 12 weeks, and significant results are typically experienced after around 28 weeks