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Division of Cardiothoracic Surgery, Department of Surgery, The Warren Alpert Medical School of Brown University OPEN ACCESS PUBLISHED: 30 November 2025 CITATION: Zheng, C., Stone, C., et al., 2025

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Subsequent internal validation on a cohort of 121,578 participants demonstrated high accuracy, with an area under the receiver operating characteristic curve (AUC) of 0.842 ( 5.2 Robust performance and persistent challenges The remarkable performance of DeepDKD is not an isolated phenomenon but is instead reflective of the broader, high-performing potential of ML in DKD risk prediction, as confirmed by a recent systematic review and meta-analysis ( 5.3 Translational challenges and future directions for AI in DKD The promising performance of AI models must be tempered by a clear-eyed assessment of the barriers to their clinical implementation