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Petersburg Institute of Bioregulation and Gerontology, Epithalon (also known as Epitalon or Epithalamin) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly

Elimination occurs primarily through renal excretion of metabolites, with the peptide and its fragments detectable in urine for up to 4 days following administration despite plasma clearance within hours

DSIP was first isolated by Schoenenberger and Monnier at the University of Basel in the 1970s during cross-circulation studies in rabbits, where blood from sleeping animals appeared to contain a sleep-promoting factor

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