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The search for safe and effective pharmacologic weight-loss agents began in the late 19th century with the discovery that sheep thyroid extract increased metabolic rate and induced significant weight loss

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In a randomized clinical trial, tesamorelin reduced visceral adipose tissue and liver fat in HIV-infected patients (Stanley et al., JAMA, 2014), and its Phase 3 program (Falutz et al.) established the visceral-fat effect that underpins its FDA approval

it binds to toxins and heavy metals, helping the body flush them out