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Intranasal injection in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine PD mouse models was done to assess the in vivo performance of these carriers

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Among these proteases, class I (HDAC1/2/3/8), class IIa (HDAC4/5/7/9), class IIb (HDACs 6/10) and class IV (HDAC11) are zinc-dependent family of enzymes, while class III (also called sirtuins (SIRTs), including SIRT1-7) are nicotinamide adenine dinucleotide (NAD + )-dependent deacetylases [52], as summarized in Table 1