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In the pivotal 64-week study of oral semaglutide 25 mg, average weight reduction landed in the mid-teens versus low single digits with placebo, with higher-response groups achieving larger losses in a meaningful subset, as reported in The New England Journal of Medicine and summarized for clinicians by the American College of Cardiology

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In the absence of leptin, increased innervation of CRH neurons by PPG-derived axons were particularly pronounced, while there was no change in the density of PPG inputs onto Oxytocin neurons