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The main mechanism of action of Phentermine/Topiramate extended release(ER) is possibly the alteration of various neurotransmitters, including inhibition of voltage-dependent sodium channels, glutamate receptors, and carbonic anhydrase as well as potentiation of -aminobutyrate activity (83).Two large randomized, double-blind, placebo-controlled trials took place (EQUIP and CONQUER) followed by a 2-year extension trial (SEQUEL)

Without Modifier 59, the payer may bundle one into the other and pay only the higher-weighted code

Injections are delivered with a small insulin-size needle into the subcutaneous fat, usually the abdomen or thigh, with daily site rotation to prevent tissue buildup

Co-destructive factors of marginal periodontitis and repetitive mechanical injury