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Semaglutide has a longer half-life (approximately 7 days) compared to tirzepatide (approximately 5 days), which means the wearing-off effect is less pronounced with semaglutide

It is non-toxic at topical concentrations and shows no evidence of irritation in human studies 6

[DOI] [PubMed] [Google Scholar] 97.Li C., Zhang W.J., Choi J., Frei B

Here is how the leading options stack up: | Feature | Semaglutide | Tirzepatide | Retatrutide | Liraglutide | |---------|-------------|-------------|-------------|-------------| | **Mechanism** | GLP-1 | GLP-1 + GIP | GLP-1 + GIP + Glucagon | GLP-1 | | **Dosing** | Weekly | Weekly | Weekly | Daily | | **Max Dose** | 2.4mg | 15mg (FDA) | 12mg (trial) | 3mg | | **Avg Weight Loss** | 15-17% | 20-22% | 22-24% | 8-10% | | **FDA Approved** | Yes | Yes | Phase 3 | Yes | | **Oral Option** | Yes (Rybelsus) | No | No | No | ## Semaglutide (Ozempic / Wegovy): The Proven Standard Semaglutide was the medication that transformed obesity treatment from a niche specialty into mainstream medicine