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They act as cofactors for enzymes involved in metabolism, nutrient conversion, neurotransmitter production and cellular function

Digoxin + Amiodarone / Verapamil Mechanism: P-glycoprotein inhibition digoxin serum concentration toxicity 10

Standalone MeaB Initial structures of dimeric MeaB in the apo-, product GDP- substrate GMPPNP-bound states were rather similar (Figure 43A), with the nucleotides of each protomer far apart, thus inconsistent with the dimer structures of HypB and UreG (Figure 36A,B)