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Within the classical pyroptosis-regulated pathway, the NLRP3 inflammasome activates the protein hydrolase caspase-1, which subsequently regulates the maturation of protein hydrolysis of GSDMD as well as IL-1 and IL-18, and the N-terminus of the hydrolyzed GSDMD pores in the cell membrane, releasing a large amount of inflammatory factors and cellular contents, which ultimately leads to pyroptosis (159)

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