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The increasing global cancer burden, with an estimated 20 million new cases and 9.7 million deaths globally in 2022 with projections indicating a 77% increase in incidence by 2050 and the limitations of current treatments, which are exemplified by the fact that despite advancements in cancer detection, treatment and supportive care, survival outcomes remain suboptimal for many patients, together highlight an unmet need for novel therapeutic agents that are both effective and safe (1)