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Traditionally, it was believed that apoptotic cells, when rapidly phagocytosed, underwent a silent death that did not elicit an immune response

The majority of studies report results on CSF 5-HIAA levels, with the controversial results based on short series of cohorts of patients with PD or other parkinsonian syndromes

Conversely to the use of inhibitors, due to the interest in promoting maintenance of NAD + levels in aging and age-associated conditions, the development of NAMPT activators has been the emphasis of recent investigation