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The bigger your GST-fusion protein is, the lower the binding capacity will be (Figure 2)

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Records that were clearly irrelevant, of low methodological quality, or outside the defined scope were excluded

On one hand, gut dysbiosis facilitates ferroptosis by affecting iron metabolic pathways, like blocking the synthesis and release of hepatic hepcidin and expression of the iron transporter FPN1 to inhibit iron efflux and causing systemic and local iron overload in joints, thus leading to ferroptosis in OA chondrocytes