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Seek emergency medical attention immediately (call 911 in the US) if experiencing: Sudden onset of severe shortness of breath or difficulty breathing Chest pain or pressure accompanying breathing difficulties Rapid heart rate, dizziness, or feeling faint Swelling of the face, lips, tongue, or throat Wheezing, stridor, or audible breathing difficulty Blue discoloration of lips or fingertips (cyanosis) Inability to speak in complete sentences due to breathlessness Confusion or altered mental status These symptoms may indicate serious conditions including anaphylaxis, pulmonary embolism, acute cardiac events, or severe metabolic derangements requiring immediate intervention

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