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GLP-1 RAs have been found to improve overall cardiovascular health and reduce major adverse cardiovascular events (MACE) by improving the endothelial function of the vasculature and lowering ANP (atrial natriuretic peptide) production, leading to reduced blood pressure

For instance, June 2024, the World Health Organization (WHO) issued a global warning regarding falsified semaglutide products after sustained shortages of genuine GLP-1 medicines were reported in multiple markets

Unlike markets where direct-to-consumer advertising drives demand, German growth is guideline-aligned and outcomes-dependent, with cardiometabolic evidence packages determining formulary positioning

Design trials that intentionally enroll and power for sex differences, and include reproductive-age women, menopausal women, and those on/exposed to hormone therapies