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During this phase, prolactin acts synergistically with other endocrine factors and local regulatory mechanisms in mammary glands to orchestrate systemic and tissue-specific metabolic adaptations ( de novo lipogenesis and lipid uptake in adipocytes and augmenting the lipid biosynthetic capacity in mammary epithelial cells ( 3 Clinical challenges Clinical studies have consistently reported the association between hyperprolactinemia and obesity
Kaufman KD, Olsen EA, Whiting D, Savin R, DeVillez R, Bergfeld W, Price VH, Van Neste D, Roberts JL, Hordinsky M, Shapiro J, Binkowitz B, Gormley GJ
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