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3 Going from no medication to 2.4 mg added about 11.7 percentage points of weight loss in STEP UP, whereas tripling the dose to 7.2 mg added only about 3 more

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GLP-1 receptor agonists have been shown to reduce major adverse cardiovascular events including cardiovascular death, heart attack, and stroke in patients with type 2 diabetes

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In a statement to CNBC, Lilly said it needs more time to gather and verify the manufacturing and quality-control data required by regulators before it can seek approval

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doi: 10.1371/journal.pone.0260549 22 ZhengZ.WuK.RuanQ.LiD.LiuW.WangM.et al

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