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Protease Inhibitor Agents Doxycycline Doxycycline (DOX) is an antibiotic used to treat bacterial infections, pneumonia, and other respiratory tract infections that has been reported to exhibit non-specific matrix metalloproteinase (MMPs) inhibitory activity ( Experimental Studies It was reported that doxycycline (2 mg/kg, p.o.) reduced lung pathology (neutrophil migration, septal thickening, and alveolar destruction), intra-alveolar inflammatory cells (mainly neutrophils), bacterial number, and MMP-2 and MMP-9 lipopolysaccharide-induced lung injury in C57Bl/6 mice ( Administration of doxycycline (2 mg/kg) in the drinking water in mice challenged with intratracheal LPS, significantly decreased the number of neutrophils and shed syndecan-1 in BALF

Similar content being viewed by others Introduction Many species of bacteria are commensals in the human oral cavity

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