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Description

In G6PD-deficient red blood cells, the NADPH needed to reduce MB (and methemoglobin) is insufficient, causing MB to instead induce oxidative stress on the cells

Nature cell biology

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The fetal liver exhibited higher mitochondrial activity and increased mitochondrial DNA copy numbersboth indicative of enhanced energy metabolismwithout major shifts in gene expression, suggesting that regulation may occur at the protein level (Safain et al., 2025)