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Among the operative mechanisms, protective effects of SEMA on cardiac remodelling with decreased hypertrophy and fibrosis with improved mitochondrial function, microvascular function and reduced apoptosis have been postulated in both experimental and clinical models,27,28 as well as other metabolic effects related to fat mass reduction (Fig

2018a, b)

The medication works by influencing the brains hunger signals, and higher doses can enhance these effects, leading to a more noticeable reduction in cravings and an increased feeling of fullness