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Yes, vitamin injections can interact with certain medications or supplements

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Vitamin B12 and Nerve Health: Why It Matters Vitamin B12 for Red Blood Cell Support and Anemia Prevention Medical Safety Note B12 injections should be used only as prescribed

Unlike oral supplements, an injection delivers vitamin B12 directly into the body without relying on digestive absorption which can be reduced by age, certain medications such as proton pump inhibitors or metformin, or gastrointestinal conditions