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In cultured fibroblasts, GHK-Cu increased collagen synthesis at strikingly low concentrations the effect began between roughly 10 -12 and 10 -11 M and peaked near 10 -9 M, independent of any change in cell number, meaning the peptide upregulated matrix production per cell rather than simply growing more cells

[DOI] [PMC free article] [PubMed] [Google Scholar] 212.Garreta E, Gasset D, Semino C, Borros S