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Profiling of drug resistance in Src kinase at scale uncovers a regulatory network coupling autoinhibition and catalytic domain dynamics

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Atay S, Correa A, Hofstetter WL, Mehran RJ, Rice DC, Roth JA, Sepesi B, Swisher SG , Vaporciyan AA, Walsh G, Antonoff MB

From the outset, Smith was interested in asking the mechanistic questions to work out why some people respond to a particular drug and some dont. The EMI post allowed Smith to develop her own ideas and to take on her first role as Chief Investigator in a national study, looking at responses to vaccines in vasculitis patients