Mutations in the KCNJ11 gene are associated with MODY13, transient neonatal diabetes mellitus type 3 (TNDM3), permanent neonatal diabetes mellitus (PNDM), familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), and also contributes to an autosomal dominant form of type 2 diabetes
A preclinical study found that TRZ-inducing weight loss regulates adipocytokines, including adiponectin and leptin, in obese mice (Samms et al
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Dysregulated insulin signalling and neuronal insulin resistance occurs in SNCA mutant neurons To assess the integrity of dynamic neuronal insulin signalling, day-55 post-differentiation mDA neurons were selected and cultured for a further 7 days +/-25nM exenatide, and then incubated overnight without insulin
