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Packing effects can drive a shift in the overall coordination geometry of higher coordination number complexes, for which packing effects are significant relative to the small difference in energy between geometries

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The implication of GST polymorphisms may be significant as studies suggest that that loss of mu, pi and theta GST genes increase susceptibility to inflammatory diseases, and a genetic deficiency of GSTM1 is associated with increased susceptibility to ozone-related asthma [61] and to susceptibility to AFB1-mediated damage to human liver cells [62]

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