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Statistical analysis Measures of central tendency and dispersion were calculated, including geometric means, medians, 25th and 75th percentiles, minimum and maximum for total, pro- and mature BDNF levels

Vitamin C for Glutathione Recycling Vitamin C (ascorbic acid) supports glutathione function through multiple mechanisms including regenerating oxidized glutathione back to its reduced, active form and providing complementary antioxidant protection that reduces the overall oxidative burden on glutathione systems

Figure 1 Evidence-based effects of key nutrients After understanding the pathological connection between nutrients and OA and discovering the significant role of the metabolism-inflammation-oxidative stress network in it, this study explores key nutrients that can prevent or treat OA through evidence-based medicine and reveals the mechanisms by which they exert preventive or therapeutic effects (Table 1)